Table 1 Demographic, clinical, and radiographic summary of all reported solitary HCC-skull metastasis without known primary HCC [6]
From: Lytic bone lesion of the skull as a rare manifestation of hepatocellular carcinoma: a case report
Authors | Patient age and gender | Prior liver disease | Clinical presentation | Image type | Image characteristics | Tumor largest dimension (cm) | Tumor size (cm) | Tumor loctation |
|---|---|---|---|---|---|---|---|---|
Sherif Wael (2025) | #, M | Hepatitis C | Swelling in the head | CT | Heterogenous enhancement: well defined | 5.3 | 5.3 × 4.9 | R, Occipital |
Bernstein and Cory et al. (2023) [6] | #, M | HCC | Bump on head with headache | CT | Heterogenous enhancement: well defined | 5 | 5 × 4.5x2.2 | L, parietal |
Bernstein (2022) | #, M | HCC | Bump on head with headache | CT | Heterogeneous enhancement: well-defined | - | - | I, parietal |
Ferraz et al. (2016) [12] | #, M | None | Bump on head with local pain | T1 MRI | Homogenous gal enhancement well-defined | # | 11 × 10x5 | R,frontal |
Subasinghe et al. (2015) [9] | #, M | Alcohol abuse | Painless bump on head (nonmovable) | XR CT | Unavailable | # | # | Midline occipital |
Jiang et al. (2014) [5] | #, M | Hepatitis B | Painless bump on head (nonmovable) | CT T1 MRI T2 MRI | Homogenous gal enhancement well-defined | 5 | 5 × 5 | R parieto-occipital |
Trivedi et al. (2009) [10] | #, M | None | R 3,4 5 cranial nerve palsy (ptosis, restricted movement, diplopia of R eyeball) | T1 MRI T2 MRI | Heterogenous | - | unavailable | Sellar, parasellar, sphenoid, extending to clivus |
Shim et al. (2008) [13] | #, M | None | Nonmovable mass; intermittent mild tenderness | T1 MRI T2 MRI | Homogenous gal enhancement well-defined | 4 | 3 × 4 | Midline occipital |