Fig. 1

Kaplan-Meier survival curves for total knee replacement. a Osteoarthritis severity (Kellgren-Lawrence grade 3 vs. 4); (b). Responders to treatment (≥20% improvement in pain by week 20); (c). LMWF-5A vs. saline in patients with severe osteoarthritis (Kellgren-Lawrence grade 4); (d). LMWF-5A vs. saline in responders to treatment with severe osteoarthritis